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They block the normal increase in expression of endothelial adhesion molecules (ie, ELAM-1) and intercellular adhesion molecules (ie, ICAM-1), and they induce lipocortin, a protein inhibitor of phospholipase A 2 (PLA2). Because PLA2 is an enzyme involved in prostaglandin synthesis, glucocorticoids ultimately decrease the synthesis and release of prostaglandin mediators of cell adhesion. Glucocorticoids also inhibit synthesis of plasminogen activator and migration inhibitory factor, 69, 70 stabilize lysosomes (thereby decreasing the release of hydrolytic enzymes and histamine 71 ), and decrease binding of chemokines that attract white blood cells. It is well known that hypocorticism results in hypertrophy of lymphoid tissue (ie, thymus, spleen, lymph nodes) and hypercorticism leads to dimunition or total loss of these tissues. Glucocorticoids induce rapid apoptosis in lymphatic tissue in rats and mice, but these effects seem to occur only at pharmacologic doses in man. The effects seen in humans, therefore, may be due to changes in the rate of formation or destruction of lymphoid cells that become evident over a longer period of time. More acute effects of glucocorticoid on lymphoid cells in man are probably caused by sequestration of the cells rather than by cell lysis, although there is evidence that certain types of activated T lymphocytes are susceptible to glucocorticoid-induced apoptosis. Glucocorticoids decrease the secretion of interleukin 1 and other mediators of immune response, inhibit lymphocyte participation in delayed hypersensitivity reactions, and interfere with the rejection of immunologically incompatible graft tissue. High doses of glucocorticoids inhibit immunoglobulin synthesis, kill B cells, 74 and decrease production of components of the complement system. Other effects of prolonged glucocorticoid therapy include ophthalmologic (posterior subcapsular cataracts, 76 increased intraocular pressure 77 ) and dermatologic (redistribution of subcutaneous fat, hirsutism, alopecia, impaired wound healing, purpura, purple striae, and acneiform eruptions 78 ) problems. Long-term glucocorticoid treatment, with the concomitant immunosuppression, also leaves patients susceptible to invasive diseases such as Kaposi sarcoma 79 and fungal infections, legal steroids promo code. By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed. Steroids And Their Harmful Side Effects. The term steroids normally are associated with reference to a class of drugs that are used to treat a variety of medical conditions. Steroids have several uses for medical purposes, such as maintaining sexual characteristics in males following surgery for removal of testes following testicular cancer, in adolescent males suffering with malfunction of the pituitary gland, and following surgery and cancer that involves loss of muscle tissue. These drugs are also used for supporting reproduction, regulation of the metabolism and immune functions. Also used for increasing muscle mass, bone mass, inflammation and other medical conditions. Anabolic Steroids (AAS) ‘Anabolic means use of something that causes a building up of tissue. The term anabolism refers more generally to an increase in lean tissue in particular muscle tissue’. Anabolic steroids or more precisely anabolic androgenic steroids (AAS) are a class of synthetic drugs that are designed to mimic the effects of the hormone testosterone. Testosterone is derived in the body from cholesterol, and like other steroid hormones, testosterone has its main effect on tissues. Testosterone enters a body cell and attaches to a receptor which crosses into the cell nucleus where it activates the synthesis of protein. Protein synthesis leads to tissue repair and growth. If we are able to increase protein synthesis it would lead to quicker regeneration of the body, and to give faster recovery from illness and injuries. A steroid used in the treatment of medical conditions usually involves the use of only one type of steroid and medical patients are closely monitored and the doses used are approximately that which would be produced naturally by the human body.
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